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. 2020 Jul 31;14:791. doi: 10.3389/fnins.2020.00791

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Copyright © 2020 Yang, Zhou, Sun, Luo, Shen and Shao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mammalian sirtuins. Mammals have seven sirtuins. They are classified into four groups. SIRT1, 2, 3 are class I, SIRT4 is class II, SIRT5 is class III, and SIRT6, 7 are class IV. All of them have a conserved NAD⁺-dependent catalytic core domain. Each of the sirtuins has unique additional N-terminal and C-terminal sequences. SIRT1, 5 tend to show NAD⁺-dependent deacetylase (DAC) activity first whereas SIRT4, 6 are likely to express its mono-ADP-ribosyl transferase (ART) activity. Sirtuins have distributed cellular localization, mitochondria (SIRT3, 4, 5), cell nucleus (SIRT6), nucleolus (SIRT7), and both in cytoplasm and nucleus (SIRT1, 2). Reprinted and modified from International Journal of Biological Sciences, 7 (5), Xiaoling Li, Mammalian Sirtuins and Energy Metabolism, 575–587, 2011 (Li and Kazgan, 2011).