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. 2020 Jul 31;11:848. doi: 10.3389/fphys.2020.00848

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Copyright © 2020 Ikonomi, Kühlwein, Schwab and Kestler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BMI1 loss impairs self-renewal (left part). An in silico knockout of BMI1 impairs cell cycle entry for all HSC populations. Proteins are listed on the left with their pathway affiliations. TP53 partially rescue a BMI1 knockout (right part). An in silico knockout of BMI1 and TP53 rescues a the impact of a loss of BMI1 by impairing apoptosis. Proteins are listed on the left with their pathway affiliations. The state of each protein is represented by colored rectangles. Activity is represented in light green and inhibition in dark blue.