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. 2020 Jul 31;11:848. doi: 10.3389/fphys.2020.00848

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Copyright © 2020 Ikonomi, Kühlwein, Schwab and Kestler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TP53 and MEF knockouts. TP53 knockout has minor impact on HSC populations. An in silico knockout of TP53 causes loss of GFI1 in LT-HSCs and increased ROS levels. ST-HSC and cycling ones are not impacted. Proteins are listed on the left with their pathway affiliations. The state of each protein is represented by colored rectangles. Activity is represented in light green and inhibition in dark blue. MEF knockout stabilizes TP53. An in silico knockout of MEF stabilized TP53 and enhanced quiescence. Here, ST-HSC and cycling HSCs show activity of GFI1 and cycling HSCs are impaired in entering S-phase. Proteins are listed on the left with their pathway affiliations. The state of each protein is represented by colored rectangles. Activity is represented in light green and inhibition in dark blue.