Table 1.

Boolean functions for the HSC model.

Node	Boolean function
External quiescence	External quiescence
External cycling	External cycling
PI3K	RAS
TSC1/2	¬AKT
mTORC1	¬TSC1/2
FOXO3A	External quiescence ∧¬AKT
ATM	FOXO3A
Mitochondria	mTORC1
ROS	Mitochondria ∨¬ATM ∨¬ FOXO3A ∨¬BMI1 ∨¬ TP53
Autophagy	FOXO3A ∧ ROS ∧¬ mTORC1
RAS	External cycling
ETS	RAS ∧¬ MEF
MEF	RAS
GSK3β	¬AKT
CTNNB1	¬GSK3β
cMYC	CTNNB1 ∧¬GSK3β
BMI1	cMYC ∨ (FOXO3A ∧ ATM)
MDM2	(TP53 ∨ MEF) ∧¬CDKN2D ∧¬ATM
TP53	¬MDM2
CDKN1C	External quiescence ∨ FOXO3A
CDKN1A	(TP53 ∨ FOXO3A ∨ External quiescence ∨ GFI1) ∧¬cMYC
CDKN1B	FOXO3A
GFI1	TP53
RB	¬CCND1 ∧¬CCNE1
E2F	¬RB ∧¬ GFI1
CCND1	¬CDKN2A ∧¬ CDKN1C ∧ cMYC
CCNE1	¬CDKN1C ∧ ((¬CDKN1A ∧¬CDKN1B) ∨ CCND1) ∧ E2F
S-phase	E2F ∧ CCNE1
AKT	PI3K
CDKN2A	(ETS ∨ ROS) ∧¬BMI1
CDKN2D	(E2F ∨ ROS) ∧¬BMI1
Pro-apoptotic proteins	ROS ∧ TP53 ∧¬AKT
Anti-apoptotic proteins	(RAS ∨ External quiescence) ∧¬GSK3β
CYCS	Pro-apoptotic proteins ∧¬Anti-apoptotic proteins
Apoptosis	CYCS ∧¬AKT
Senescence	(CDKN2A ∧ ROS) ∨ (TP53 ∧ ROS ∧ CDKN1A)

Compounds are abbreviated according to accepted nomenclature. Regulatory interactions are summarized by logical connectives AND (∧), OR (∨), and NOT (¬). References for each Boolean function are provided in the Supplementary Section 1.1.