Table 2.
Summary of analyzed attractors.
| Attractor | Process | Phenotypical description | Associated HSC phenotype |
|---|---|---|---|
| LT-HCS | Metabolism | Inactive ROS | Quiescent |
| Metabolism | Inactive mTORC1 | ||
| Metabolism | Active FOXO3A | ||
| Cell cycle | Inactive MYC | ||
| Cell cycle | Active TP53 | ||
| Cell cycle | Active CDKN1C | ||
| Cell cycle | Active CDKN1A | ||
| Cell cycle | Active CDKN1B | ||
| Cell cycle | Active GFI1 | ||
| Cell cycle | Inactive S-phase | ||
| ST-HSC | Metabolism | Active ROS | Activated HSC |
| Metabolism | Active mTORC1 | ||
| Metabolism | Inactive FOXO3A | ||
| Cell cycle | Active MYC | ||
| Cell cycle | Inactive TP53 | ||
| Cell cycle | Active CDKN1C | ||
| Cell cycle | Inactive S-phase | ||
| Cycling HSC | Cell cycle | Active CCND1 | Proliferating HSC |
| Cell cycle | Active CCNE1 | ||
| Cell cycle | Active S-phase | ||
| Unstimulated | External Stimuli |
– | – |
Main nodes discussed in the text, final biological interpretation and references are reported for each obtained attractor. A version with references is provided in the Supplementary Section 1.2.