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. 2020 Jul 31;11:633. doi: 10.3389/fgene.2020.00633

Table 7.

Diagnostic value of 19 CpG sites of SOX1 promoter for HSIL.

CpG Sites Locationa Position to TSSa CpG Feature Typea,b Studies Nc Sample size (CC/controls) Diagnostic value of CpG sites for HSIL P-value
Cut-off β value Sensitivity (%) Specificity (%) AUC
cg20194811 chr13:112066177 −1471 N_Shore 2 53/48 0.056 0.392 0.830 0.605 0.048
cg01757312 chr13:112066251 −1397 Island 2 53/48 0.222 0.608 0.679 0.648 0.007
cg20829347 chr13:112066613 −1035 Island 2 53/48 0.191 0.922 0.453 0.683 1.26E-04
cg24604013 chr13:112067011 −637 Island 2 53/48 0.171 0.863 0.340 0.616 0.032
cg27301032 chr13:112067111 −537 Island 2 53/48 0.091 0.608 0.660 0.676 0.002
cg25463470 chr13:112067398 −250 Island 2 53/48 0.062 0.824 0.528 0.674 0.001
cg00663972 chr13:112067411 −237 Island 2 53/48 0.136 0.941 0.358 0.673 0.001
cg11199713 chr13:112067459 –189 Island 2 53/48 0.208 0.804 0.623 0.729 8.27E-06
cg19407095 chr13:112067464 –184 Island 2 53/48 0.228 0.824 0.623 0.725 1.09E-05
cg06675478 chr13:112067472 −176 Island 3 63/51 0.302 0.961 0.453 0.721 1.03E-05
cg02547394 chr13:112067475 −173 Island 2 53/48 0.153 0.490 0.830 0.701 1.03E-04
cg16705627 chr13:112067636 −12 Island 2 53/48 0.249 0.647 0.642 0.670 1.06E-03
cg15466862 chr13:112068019 371 Island 2 53/48 0.108 0.569 0.774 0.686 9.41E-04
cg19802138 chr13:112068405 757 Island 2 53/48 0.276 0.745 0.585 0.642 0.017
cg04865691 chr13:112069107 1459 Island 2 53/48 0.252 0.843 0.396 0.646 0.002
cg04047221 chr13:112069163 1515 Island 2 53/48 0.091 0.529 0.717 0.632 0.004
cg01236132 chr13:112069267 1619 Island 2 53/48 0.239 0.588 0.660 0.609 0.067
cg00073003 chr13:112070269 2621 S_Shore 2 53/48 0.217 0.490 0.736 0.584 0.072
cg22303211 chr13:111771727 – Island 1 10/3 0.282 0.700 1.000 0.733 0.063
a

Information for position of CpG site according to TCGA data.

b

Island is the start coordinates of CpG island; N_Shore is 0-2 kb upstream from the position of CpG island; S_Shore is 0-2 kb downstream from the position of CpG island.

c

GSE99511 and GSE46306 used the Illumina HumanMethylation 450K BeadChip, which included methylation probes of all CpG island except cg22303211 in SOX1 promoter; GSE41384 used the Illumina HumanMethylation 27K BeadChip, which included methylation probes of cg06675478 and cg22303211.