Table 2.

The association between T2D and/or prevalent VFs with incident nonvertebral fractures, overall and stratified by BMD category

	Outcome: incident nonvertebral fracture, HR (95% CI)
Without T2D or VFs (reference)	1.00	1.00	1.00	1.00
With VFs alone	1.39 (1.27–1.52)	1.61 (1.29–2.00)	1.41 (1.26–1.59)	1.32 (1.13–1.55)
With T2D alone	1.24 (1.09–1.40)	1.22 (0.98–1.52)	1.28 (1.08–1.52)	1.04 (0.71–1.51)
With both T2D and VFs	2.42 (1.86–3.15)	2.50 (1.44–4.35)	2.58 (1.76–3.79)	2.06 (1.25–3.38)
With VFs alone (reference)	1.00	1.00	1.00	1.00
With both T2D and VFs	1.73 (1.32–2.27)	1.55 (0.86–2.78)	1.82 (1.23–2.70)	1.55 (0.93–2.57)
With T2D alone (reference)	1.00	1.00	1.00	1.00
With both T2D and VFs	1.94 (1.46–2.59)	2.04 (1.14–3.65)	2.00 (1.33–3.03)	1.97 (1.07–3.62)

Data are results obrained from Cox regression model adjusted for age (natural splines with 6 df), BMI (natural splines with 5 df), sex, corticosteroid use, antiosteoporotic treatment, and study. The analysis without stratification was additionally adjusted for BMD measured at the femoral neck.