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. 2020 Jul 31;11:1171. doi: 10.3389/fphar.2020.01171

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Copyright © 2020 Brunetti, Bottani, Segala, Marchet, Rossi, Orlando, Malavolta, Carruba, Lamperti, Provinciali, Nisoli and Valerio

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neuromuscular and cognitive phenotypical characterization of SAMP8 mice at different ages. (A) Representative pictures of SAMP8 mice at 5, 9, 12, and 15 months of age show a progressive appearance of signs of aging, which were quantified by means of body condition score (B), body weight (C), frequency of kyphosis (D), and frequency of hind limb clasping reflex (E). SAMP8 mice also showed a progressive reduction in exercise endurance measured by treadmill exhaustion test (F), which was paralleled by a decline of working memory quantified by Y-maze test (G). Statistical analyses were performed with one-way ANOVA and Tukey’s multiple comparison test (B, C, F, G) or Fisher test (D, E). Error bars represent SEM; n=6 mice/group; **p < 0.01, ***p < 0.001.