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. 2020 Jul 9;22(3):2573–2582. doi: 10.3892/mmr.2020.11313

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Copyright: © Zeng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Effect of Sphk2-siRNA, Smad7-pcDNA and Sphk2-siRNA + Smad7-siRNA on the expression levels of TGF-β1/Smad signaling key proteins and collagen I in HSF. Protein expression levels of (A) TGF-β1 and (B) collagen I, p-Smad2 and p-Smad3 were determined using western blot analysis. ***P<0.001 vs. the control; ^#P<0.05, ^##P<0.01, ^###P<0.001 vs. Sphk2-NC; ^∆P<0.05 vs. Sphk2-siRNA. All experiments were repeated three times independently. Data are presented as the mean ± SD. Sphk2, sphingosine kinase 2; siRNA, small interfering RNA; TGF-β1, transforming growth factor-β1; NC, negative control; HSF, hypertrophic scar fibroblasts; p-, phosphorylated.