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. 2020 Jun 23;22(3):2052–2062. doi: 10.3892/mmr.2020.11266

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Statin rosuvastatin suppresses the apoptosis of HCAECs through regulation of the JAK2/STAT3 pathway. (A) JAK2 selective inhibitor AG490 decreased and abolished statin-regulated JAK2, p-JAK2, STAT3 and p-STAT3 expression in the HCAECs. (B) JAK2 selective inhibitor AG490 decreased and abolished statin-inhibited apoptosis of HCAECs (magnification, ×50). (C) Effects of JAK2 selective inhibitor AG490 on statin-regulated Bcl-xl and Bcl-2 protein expression in the HCAECs. (D) Effects of JAK2 selective inhibitor AG490 on statin-regulated Bax and Bad protein expression in the HCAECs. (E) Effects of JAK2 selective inhibitor AG490 on statin-regulated Bcl-xl and Bcl-2 gene expression in the HCAECs. (F) Effects of JAK2 selective inhibitor AG490 on statin-regulated Bax and Bad gene expression in HCAECs. **P<0.01; ns, not significant; HCAEC, human coronary artery endothelial cells; JAK, Janus kinase; p-, phosphorylated; STAT, signal transducer and activator of transcription.