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. 2020 Jun 26;22(3):1831–1838. doi: 10.3892/mmr.2020.11279

Figure 3.

Figure 3.

Effect of Prx I knockdown on the AKT/GSK-3β/β-catenin and NF-κB signaling pathways. (A) Western blot analysis of p-AKT, AKT, p-GSK3β, p-β-catenin and β-catenin protein expression in scramble and shPrx I-transduced MIN6 cells following STZ stimulation. (B-D) Relative protein expression levels p-AKT, p-GSK3β, and p-β-catenin. (E) Western blot analysis of IκBα and p-p65 protein expression in scramble and shPrx I-transduced MIN6 cells following STZ stimulation. (F and G) Relative protein expression levels of IκBα and p-p65. Data are presented as the mean ± SD. *P<0.05, **P<0.01 and ***P<0.001. STZ, streptozotocin; Prx, peroxiredoxin; GSK-3β, glycogen synthase kinase-3β; IκBα, inhibitor of nuclear factor-κB α; p, phosphorylated; shRNA; short hairpin RNA.