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. 2020 Jul 31;11:1675. doi: 10.3389/fimmu.2020.01675

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Copyright © 2020 Chen, Huang, Chen, Wu, Hsu, Tsai, Ko and Tsai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SLPs of C. difficile induced inflammasome activation. (A) SLPs were isolated from non-toxigenic C. difficile (tcdA⁻, tcdB⁻), followed by (A) SDS-PAGE and (B) western blot assays. Purified SLPs possess high molecular weight (HMW) and low molecular weight (LMW) components. M, protein markers with molecular weights in kDa. The production of matured caspase-1 and IL-1β were increased by SLP treatment as well as C. difficile infection (C), and in a dose-dependent manner (D). (E) Matured caspase-1 and IL-1β were blockaded by anti-SLP Abs.