Table 4.
Morbidities and mortality according to treatment options.
| IV ibuprofen | Oral ibuprofen | IV paracetamol | Oral paracetamol | p | |
|---|---|---|---|---|---|
| (n = 148) | (n = 129) | (n = 108) | (n = 29) | ||
| Discharged with open PDA, n (%) | 28 (19) | 19 (15) | 24 (22) | 9 (31) | 0.18 |
| Surgical ligation, n (%) | 11 (7) | 10 (8) | 6 (6) | 2 (7) | 0.91 |
| LOS, n (%) | 82 (64) | 65 (51) | 54 (61) | 10 (53) | 0.08 |
| IVH (≥Gr 3), n (%) | 3 (2) | 6 (5) | 5 (5) | 1 (3) | 0.61 |
| NEC, n (%) | 40 (27) | 32 (25) | 20 (18) | 15 (52) | 0.004 |
| Treated ROP‡, n (%) | 22 (15) | 18 (14) | 18 (17) | 5 (17) | 0.93 |
| Moderate-severeBPD¥, n (%) | 36 (44) | 39 (59) | 28 (58) | 3 (30) | 0.11 |
| Mortality, n (%) | 46 (31) | 34 (26) | 48 (44) | 16 (55) | 0.002 |
| BPD/death, n (%) | 75 (51) | 63 (49) | 71 (66) | 17 (59) | 0.04 |
BPD, bronchopulmonary dysplasia; IVH, intraventricular hemorrhage; LOS, late-onset sepsis; NEC, necrotizing enterocolitis; PDA, patent ductus arteriosus; ROP, retinopathy of prematurity.
‡
Infants had at least one eye examination for ROP.
¥
Infants survived at PMA 36 weeks' gestation.