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Toluidine blue staining of articular cartilage in OA rats identified that genistein upregulates acid glycosaminoglycan content. The content of acid glycosaminoglycan in the cartilage matrix was significantly decreased in the OA group and increased in the genistein group. Scale bar, 50 µm. Arrow indicates the blue stained acid glycosaminoglycan. OA, osteoarthritis.
