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Genistein decreases the levels of TNF-α and IL-1β in the synovial fluid of OA rat model. Compared with the normal group, levels of (A) TNF-α and (B) IL-1β in the OA group were significantly increased, as measured using ELISA. In the genistein group, TNF-α and IL-1β were decreased compared with the OA group. Data are presented as the mean ± SD (n=10). **P<0.01 vs. the normal group; ##P<0.01 vs. the OA group. IL, interleukin; OA, osteoarthritis; TNF, tumor necrosis factor.
