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. 2020 Jul 9;22(3):2263–2272. doi: 10.3892/mmr.2020.11315

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Copyright: © Lan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Effects of shikonin in an IMQ-induced psoriatic mouse model. Individual Psoriasis Area Severity Index score for (A) skin thickness, (B) scaling and (C) erythema. (D) Cumulative score in the different experimental groups. Data are presented as the mean ± SEM. n=5. (E) Histological analysis of the affected dorsal skin using hematoxylin and eosin staining. Magnification, ×200. (F) Representative images illustrating gross phenotypic changes in the skin lesions after 8 days of treatment. IMQ, imiquimod, SO, shikonin oil; MO, medium oil; CON, control.