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. 2020 Jul 8;22(3):2174–2182. doi: 10.3892/mmr.2020.11309

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — TMZ attenuated hepatic lipid accumulation and lipogenic gene expression in vivo. (A and B) Hepatic TG and TC in treated mice. (C) Relative mRNA levels of ChREBP, ACC and FASN in liver of treated mice. (D-F) Protein levels of ChREBP and AMPK in liver of treated mice. (^#P<0.05 vs. NCD group, ^##P<0.01 vs. NCD group, ^###P<0.001 vs. NCD group, ^####P<0.0001 vs. NCD group, *P<0.05 vs. HFD group, **P<0.05 vs. HFD group, ***P<0.05 vs. HFD group.) TMZ, trimetazidine; NCD, normal chow diet; HFD, high fat diet; TG, triglyceride; TC, total cholesterol; ChREBP, carbohydrate-responsive element-binding protein; ACC, acetyl-CoA carboxylase; FASN, fatty acid synthase; AMPK, AMP-activated protein kinase.