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. 2020 Jun 23;22(3):1811–1820. doi: 10.3892/mmr.2020.11268

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Copyright: © Shi et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Functional role of HOTAIR during the proliferation and differentiation of ESCs. (A) Cell proliferation was examined by BrdU incorporation assay. (B) Cell proliferation was examined by MTT assay. (C) The mRNA expression of NANOG was upregulated in the pc-HOTAIR group and the differentiation potential was suppressed. Values are presented as the mean ± standard deviation from at least three independents. *P<0.05 pc-HOTAIR group vs. pc-vector and con-ESCs groups. ^#P<0.05 sh-HOTAIR group vs. sh-NC and con-ESCs groups. HOTAIR, HOX antisense intergenic RNA; ESC, epidermal stem cell; NC, negative control; sh, short hairpin RNA; con, parental control cells; pc, overexpression plasmid; BrdU, 5-bromodeoxyuridine.