Figure 2.

Effect of PMG on escape latency time under cognitive deficit induced by Rt. MCAO. Data are presented as mean ± SEM (n = 6/group). ^ap value < 0.05, ^aap value < 0.01, and ^aaap value < 0.001; compared between naïve control which received a normal diet and vehicle and MetS+MCAO rats which received HCHF, MCAO, and vehicle. ^bp value < 0.05, ^bbp value < 0.01, and ^bbbp value < 0.001; compared between sham rats which received HCHF, sham operation, and vehicle and MetS+MCAO rats which received HCHF, MCAO, and vehicle. ^∗p value < 0.05 and ^∗∗p value < 0.01; compared to MetS+MCAO rats which received HCHF, MCAO, and vehicle. ND: normal diet; HCHF: high-carbohydrate high-fat diet; MetS: metabolic syndrome; MCAO: middle cerebral artery occlusion; Vitamin C: vitamin C at a dose of 250 mg·kg⁻¹ BW; Donepezil: donepezil at a dose of 3 mg·kg⁻¹ BW; PMG50, PMG100, and PMG200: the phytosomes containing the combined extract of mulberry fruit and ginger at doses of 50, 100, and 200 mg·kg⁻¹ BW, respectively.