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. 2020 Aug 6;9:F1000 Faculty Rev-935. [Version 1] doi: 10.12688/f1000research.25607.1

Figure 4. Apoptotic signaling through membrane (lipids)-mediated spontaneous activation of Bax/Bak.

Figure 4.

A) The intrinsic (mitochondrial-dependent) apoptotic pathway based on the membrane (lipids)-mediated spontaneous (MMS) Bax/Bak activation model. B) The intrinsic (mitochondrial-dependent) and extrinsic (death receptor-mediated) apoptotic pathways based on the MMS activation model. Apaf-1, apoptotic protease activating factor-1; Casp, caspase; Cyt c, cytochrome c; FADD, Fas associated death domain protein; MOM, mitochondrial outer membrane; SMAC, second mitochondria-derived activator of caspase; XIAP, X-linked inhibitor of apoptosis protein.