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The effects of piperlongumine (PL) and the combination with sanguinarine (SAN) on cytoskeletal proteins in A549 cells: (A,A′–D,D′)—β-tubulin, (E,E′–H,H′)—F-actin, (I,I′–K,K′)—vimentin. Significant changes are marked with arrows—protein organization in the cells with the phenotype of mitotic catastrophe (I), apoptotic phenotype (II), point accumulation of the protein (III), dispersion of the protein’s network (IV) and stress fibers (V). Bar—50 µm.
