Table 2.

Inhibition of C. Riparius and porcine kidney trehalases by compounds 12, 13, 15, 16, 19, and 20.

Compound	C. riparius, IC50 (Ki)	Porcine Kidney, IC50 (Ki)	Selectivity a
12	2.83 μM [54] (1.39 μM) [54]	5.96 μM [54] b (2.98 μM) [54]
13	55 μM [48]	n.i. [50]	18.2
15	19 μM [54] (9.3 μM) [54]	4.8 μM [50] c (5.3 μM) [54]	-
16	10 μM [52] d	n.i. [52]	100
19	9.7 μM [55]	109 μM [55]	11.2
20	11 μM [56]	76 μM [56]	6.9

^a Selectivity is the ratio between the IC₅₀ value against porcine kidney trehalase and the IC₅₀ value against C. riparius trehalase; ^b IC₅₀ = 41 μM [50] and IC₅₀ = 43 μM [21] have been previously reported; ^c IC₅₀ = 10.6 μM was also reported [54]; ^d IC₅₀ reported towards insect trehalase from Plutella xylostella instead of C. riparius; n.i.: no inhibition at 1 mM.