Table 3.
MTT assay for the antiproliferative IC50 ± SD (μM) activity of compounds 3a–e and colchicine.
| Compound | Cytotoxicity IC50 (µM) a | |
|---|---|---|
| RPMI-8226 | L.SR | |
| 3a | 1.61 ± 0.0654 *** | 1.11 ± 0.06849 *** |
| 3b | 4.62 ± 0.0459 *** | 2.02 ± 0.06875 *** |
| 3c | 9.96 ± 0.3451 *** | 4.84 ± 0.08425 *** |
| 3d | 17.81 ± 0.0544 *** | 22.06 ± 0.06792 *** |
| 3e | 3.17 ± 0.0489 *** | 5.04 ± 0.07908 *** |
| Colchicine | 4.05 ± 0.0478 *** | 1.81 ± 0.07009 *** |
a IC50 = compound concentration required to inhibit tumor cell proliferation by 50%. Data are expressed as the mean ± SD from the dose–response curves of at least three independent experiments. Results significantly different from control at *** p < 0.05.