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A schematic representation of the (GABA) type B receptor (GABAB-R) heterodimer with the extracellular Venus Flytrap domain (VFT) and the heptahelical transmembrane domain (7TM) of the GABAB1b (gray) and GABAB2 (black) protomers. The VFT is connected to the 7TM by a linker that interacts with the extracellular loop 2 (ECL2) of 7TMs (active receptor conformation (Protein Data Bank (PDB) ID: 6OU8).
