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The agonist baclofen (A) and the antagonist CGP54626 (B) in the GABAB1b VFT binding pocket surrounded with residues important for ligand binding (PDB ID: 4MS4 and 4MR7, respectively). Trp278 and Tyr250 are located in Lobe 2 of the GABAB1 VFT, whereas the remaining residues are located in Lobe 1.
