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Two HERV-K HML-2 genome types. Type I sequences have a deletion in the env gene of a 292-base pair region (∆292pb). This region has a splice donor (SD) site 2, which is absent in the HERV-K type I. Type II sequences contain two splice donor sites (SD-1 and SD-2). Differences in the presence of the SD sites are responsible for generating the distinct np9 or rec transcripts from Type I and II sequences, respectively. SA, splice acceptor site.
