Table 2.
Identified possible functions of NFP in the serum of the rat treated with NFP by Ingenuity Pathway Analysis (IPA).
| Up/Down | Total Function | Cancer-Specific | Except Cancer |
|---|---|---|---|
| Upregulated | Quantity of cells | Concentration of lipid, fatty acid | Activation of phagocytes, macrophages |
| - myeloid cells | Concentration of lipopolysaccharide | Quantity of cells | |
| - blood cells | Conjugation of glutathione | - myeloid cells | |
| Quantity of cells | Cellular infiltration by leukocytes | - leukocytes | |
| Activation of cells | - blood cells | ||
| - phagocytes | Quantity of connective tissue | ||
| - macrophages | |||
| Quantity of connective tissue | |||
| Downregulated | Cancer | Cancer Type | Apoptosis, cell death |
| - Non-Hodgkin lymphoma | - Abdominal carcinoma, malignant solid tumor | - microvascular endothelial cells | |
| - Non-small cell lung carcinoma | - Nonhematologic malignant neoplasm, lung cancer | Damage of epithelial, endothelial tissue | |
| - Binding of tumor cell lines | - Liver cancer | Apoptosis, cell death | |
| - Lung carcinoma | - Non-Hodgkin lymphoma | - Endothelial cells | |
| Brain | - Non-melanoma solid tumor | Damage of nervous system | |
| - Tauopathy | - Extracranial solid tumor | Production of reactive oxygen species | |
| - Dementia | - Digestive system cancer | Damage of endothelial cells | |
| - Ischemia of brain | - Tumorigenesis of epithelial neoplasm | Synthesis of reactive oxygen species | |
| Viral Infection | Anticancer function | Necrosis of epithelial tissue | |
| Chronic kidney disease | - Metastasis of breast cancer cell lines | Binding of neutrophils | |
| Neuromuscular disease | - Cell spreading of tumor cell lines | Organismal death | |
| Thrombosis | - Development of malignant tumor | Adhesion of myeloid cells | |
| - Thrombosis of vein | - Incidence of tumor | ||
| - Coagulation of blood | - Angiogenesis | ||
| Fibrogenesis | |||
| Synthesis of reactive oxygen species |