Table 2.
CC50/ IC50 (µg/mL) and SI values for different samples against selected cell lines.
| Sample Names | CC50 Normal Cell Line | IC50 Cancerous Cell Lines | Selectivity Indexes | ||
|---|---|---|---|---|---|
| Vero E6 | HCC 1395 | DU 145 | HCC 1395 | DU 145 | |
| myristic acid (1) | 64.86 ± 0.51 c | 57.71 ± 1.2 a | 80.24 ± 0.12 d | 1.12 | 0.81 |
| stigmasterol (2) | 123.88 ± 0.00 b | 0.42 ± 0.1 i | 140.49 ± 1.27 a | 294.94 | 0.88 |
| sesamin (3) | 135.31 ± 0.12 a | 3.39 ± 1.0 h | 115.06 ± 0.03 b | 39.97 | 1.18 |
| 8-acetonyldihydrochelerythrine (4) | 47.83 ± 1.15 e | 9.99 ± 0.6 e | 66.82 ± 0.58 e | 4.79 | 0.72 |
| arnottianamide (5) | 2.77 ± 0.12 h | 38.34 ± 0.1 b | 84.31 ± 0.64 c | 0.07 | 0.03 |
| 10-methoxycanthin-6-one (6) | 53.95 ± 0.38 d | 14.70 ± 0.5 c | 1.58 ± 0.00 i | 3.67 | 34.15 |
| canthin-6-one (7) | 41.81 ± 0.64 f | 8.12 ± 0.6 f | 9.43 ± 0.01 h | 5.15 | 4.43 |
| 8-oxochelerythrine (8) | 135.32 ± 0.12 a | 14.09 ± 0.3 d | 63.41 ± 1.10 f | 9.60 | 2.13 |
| Z. paracanthum root bark extract | 28.28 ± 0.34 g | 7.27 ± 0.0 g | 53.21 ± 1.21 g | 3.89 | 0.53 |
| Doxorubicin (Positive control) | 0.30 ± 0.12 i | 0.21 ± 0.2 i | 0.59 ± 0.01 i | 1.41 | 0.51 |
Vero E6—Normal cell line, HCC 1395—human breast cancer cell line, DU 145—human prostate cancer cell line, SI—selectivity index. Values for CC50/ IC50 are expressed as Mean ± SEM, values sharing a superscript letter in each column are not significantly different from each other (p ≥ 0.05).