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Synthetic strategy for obtaining clicked curcumin-based compounds 1 and 2. Reagents and conditions: (i) propargyl bromide, K2CO3, acetone, 80 °C; (ii) B2O3, DMF; (iii) B(n- BuO)3; (iv) vanillin, n-BuNH2, 80 °C; (v) HCl, 80 °C; (vi) NaN3, DMF, 60 °C; (vii) TEA, CuSO4, (+)-sodium L-ascorbate, DMF, r.t.
