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Synthetic strategy for obtaining asymmetric clicked curcumin-based analogs 3 and 4. Reagents and conditions: (i) B2O3, DMF; (ii) B(n-BuO)3; (iii) n-BuNH2, 80 °C; (iv) HCl, 80 °C; (v) propargyl bromide, K2CO3, acetone, reflux; (vi) selected azide (9, 10), TEA, CuSO4, (+)-sodium L-ascorbate, DMF, r.t.
