Table 1.
Demographic and clinical characteristics
| Variable | Yes EONS (n = 41) |
No EONS (n = 51) |
p-Value |
|---|---|---|---|
| Demographic and clinical characteristics | |||
| Maternal age (y)a | 26 [21–34] | 30 [22–35] | 0.637 |
| African-American raceb | 20 (49) | 25 (49) | 0.982 |
| PPROMb | 20 (49) | 30 (59) | 0.402 |
| Clinical chorioamnionitisb | 4 (10) | 8 (16) | 0.401 |
| Positive amniotic fluid Gram stainb | 36 (88) | 21 (41) | 0.003 |
| Positive amniotic fluid cultureb | 40 (98) | 24 (47) | <0.001 |
| Intra-amniotic infection (IAI)b | 40 (98) | 30 (59) | <0.001 |
| Gestational age at delivery (wks)a | 25 [24–27] | 29 [28–32] | <0.001 |
| Birthweight (g)a | 780 [675–968] | 1,370 [1,020–1,930] | <0.001 |
| Cesarean deliveryb | 12 (29) | 24 (47) | 0.091 |
| 1 min Apgar <7b | 30 (73) | 21 (41) | 0.003 |
| 5 min Apgar <7b | 17 (41) | 7 (14) | 0.004 |
| Arterial pHa | 7.32 [7.25–7.35] | 7.31 [7.28–7.35] | 1.000 |
| Funisitisbc | 0.003 | ||
| Absent | 10 (25) | 31 (61) | |
| Mild (grade 1 or 2) | 7 (18) | 4 (8) | |
| Severe (grade 3 or 4) | 23 (57) | 16 (31) | |
| Neonatal sepsis workup | |||
| Neonatal ANC (cells/mm3)a | 4,050 [1,948–7,165] | 3,861 [2,185–6,630] | 0.594 |
| Neonatal ABC (cells/mm3)a | 2,550 [1,602–3,808] | 270 [0–672] | <0.001 |
| I:T ratio (%)a | 19 [13–25] | 3 [0–7] | <0.001 |
| Hemoglobin (mg/dL)a | 13.1 [12.1–14.2] | 14.5 [13.3–16.1] | <0.001 |
| Hematocrit (%)a | 40.9 [37.3–43.8] | 44.5 [41.2–50.7] | <0.001 |
| Platelets (cells × 1000/mm3)a | 233 [157–329] | 244 [213–286] | 0.396 |
| Culture confirmed EONSb | 4 (11) | 0 (0) | 0.028 |
a
Data presented as median [interquartile range] and analyzed by Mann Whitney tests.
b
Data presented as n (%) and analyzed by Fisher Exact test.
c
Pathology results missing in one case
Abbreviations: ANC, absolute neutrophil count; ABC, absolute band count; I:T ratio, immature:total neutrophil ratio.