Table 7.
Summary of PreS2 epitopes binding to respective alleles, and mutations that exist within the Botswana HBV sequences.
| Genotype | AA Sequence Core | AA Sequence of epi | Pres2 epi Residues | Count of epi with Core AA Sequence | HLA Class II Alleles | Mutations in the Core Sequence |
|---|---|---|---|---|---|---|
| A | ALQDPRVRG | AFHQALQDPRVRGLYFPA | 7–24 | 7 | *0301∆ | R16K, V17I |
| A | ASHISSISS | VPNTASHISSISSRT | 35–49 | *0401 | A39T, I45S | |
| D | ASPLSSIFS | VPTTASPLSSIFSRIG | 35–50 | 2 | *0101, *0401 | L42I, L42S |
| A | FHQALQDPR | NSTAFHQALQDPRVRG | 4–19 | 2 | *0301, 5*0101 | A11T, R16K |
| D | FHQTLQDPR | NSTTFHQTLQDPRVR | 4–18 | 1 | *0301 | - |
| D | FSRIGDPAL | SPLSSIFSRIGDPALN | 40–55 | 1 | *0101, *0401, *0701, 5*0101 | R48T, P52H, A53V, L54P |
| A | HISSISSRT | VPNTASHISSISSRTG | 35–50 | 4 | *0101, *0401, *0701 | I45S, R48T |
| D | IFSRIGDPA | SPLSSIFSRIGDPALN | 40–55 | 2 | *0802, *1302, *1501 | L42I, L42S |
| A | ISSISSRTG | PNTASHISSISSRTGDPALN | 36–55 | 6 | *0101, *0401, *0701, *0802, *1101, *1501, 5*0101 | I45S, R48T |
| A | LNPVPNTAS | SSSGTLNPVPNTASHISSI | 27–45 | 5 | *0401, *0802 | L32H, L32R, P34L, N37H, N37T, I38T, A38T |
| D | LSSIFSRIG | PTTASPLSSIFSRIGDPALN | 36–55 | 6 | *0101, *0401, *0701, *0802, *1101, *1501, 5*0101 | P52L, A53V |
| A | MQWNSTAFH | MQWNSTAFHQALQDP | 1–15 | 1 | *1302 | Q2I, A7T |
| MQWNSTTFHQTLQDP | - | - | S5F, S5Y, T6A, T7I, T7N | |||
| D | PLSSIFSRI | VPTTASPLSSIFSRI | 35–49 | 1 | *0701 | L42I, L42S |
| A | PVPNTASHI | SSGTLNPVPNTASHISSI | 27–45 | 6 | *1302 | P34L, N37H, N37T |
| D | PVPTTASPL | VNPVPTTASPLSSIF | 32–46 | 2 | *0701 | P34H, P36L, L42I, L42S |
| A | QALQDPRVR | TAFHQALQDPRVRGLYF | 6–22 | 3 | 5*0101 | - |
| D | QTLQDPRVR | STTFHQTLQDPRVRGLYF | 5–22 | 4 | 5*0101 | R22K |
| D | TLQDPRVRG | STTFHQTLQDPRVRGLYFPA | 6 | *0301 | R18K, G19D, G19A | |
| A | VRGLYFPAG | DPRVRGLYFPAGGSSSG | 14–30 | 3 | *0802, *1101, *1501 | V17I, Y21N, Y21S, F22L, F22P, F22T, P23A |
| D | 3 | *0802, *1101, *1501 | R18K, G19D, G19A, F2222Q, F22H, F22P, F22L | |||
| A | WNSTAFHQA | MQWNSTAFHQALQDP | 1–15 | 1 | *0401, *0701 | A7T, A11T |
| D | WNSTTFHQT | MQWNSTTFHQTLQDP | 1 | *0701 | S5F, S5Y, T6A, T7I, T7N | |
| A | YFPAGGSSS | PRVRGLYFPAGGSSSGTLNP | 15–34 | 6 | *0101, *0401, *1101, 5*0101 | Y21N, Y21S, F22L, F22P, F22T, P23A, S29L |
| D | YFPAGGSSS | PRVRGLYFPAGGSSSGTVNP | 6 | *0101, *0401, 5*0101, *1101 | F22Q, F22H, F22P, F22L |
*0101 means HLA class II allele DRB1*0101 e.tc. 5*0101 means HLA class II allele DRB5*0101.