Table 2.
HBx-upregulated miRNA targets in HBV-HCC and immune pathways.
| miR | HBV-HCC Target (Hepatocytes) |
Immune Target (Hepatocytes/Leucocytes) |
Reference |
|---|---|---|---|
| miR-1 | MASPIN/HDAC4/E2F5 | HDAC4//E2F5/HSP60/HSP70/KCNJ2/GJAJ | [74,206] |
| miR-107 | AXIN2/MASPIN | CDK6 | [206,207,208,209] |
| miR-125a | ERBB2, HBsAg | TNF-α/BCL-2/KLF13/BMF | [9,108,109,140,210,211] |
| miR-143 | FNDC3B | MAPK7 | [24,212,213] |
| miR-146a | CFH/STAT1 | IRAK1/TRAF6/IL-1/IRAK2/IL-4/IFN-γ/TIRAP/ NF-κB/IFNγ/STAT1 |
[6,9,65,126,130,145,214,215,216,217,218,219,220,221,222,223] |
| miR-155 | PTEN/SOX6/ZHX2/SOCS1 | IFNγ/SHIP1/SOCSI/BMAL1/PU.1/BACH1/CSFIR/CEBPβ/AID/ETS1 | [6,9,145,221,224,225,226,227,228,229,230,231,232,233,234,235,236,237,238] |
| miR-17-92 family | E2F1, Cyclin G1/PTEN/p21/p27/p57 | Th2 induction3/SOCS1/C/EBP/AID/FOXP3/ TNFSF9/CCL-5/IKBKE/c-MAF/AMLI/TP53INPI c-MAF/IFNγ/CD69/PTEN/TGFBR11/p27/p21/E2F/PHLPP2/BIM/CREB1 |
[6,9,65,145,239,240,241,242,243,244,245] |
| miR-181a | FAS, E2F5 | AID/DUSP5/NLK/PTPN22/SHP2 /DUSP6/CD69/BCL-2 | [6,244,246,247,248,249,250,251] |
| miR-199a-5p | CHC | CD19+ | [9,121] |
| miR-203a | RAP1A | SMAD1/BCL11B/RARB/PRKCA/PRKCB1/FMRP/ | [252] |
| miR-21 | PDCD4, PTEN, MASPIN, RECK | PTEN/MYD88/IRAK1/PDCD4/SMAD7 | [65,127,164,206,253,254,255,256,257] |
| miR-215 | PTPRP | NO IDENTIFIED IMMUNE TARGET | [154,216,258] |
| miR-221 | ERα, DDIT4/BMF/p27/p57/PTEN/p21/SOCS3 | PTEN/SOCS3/p57/KIT/p27 kip- | [65,102,145,169,259,260,261,262,263,264] |
| miR-222 | P27kip−1/PTEN/PPP2R2A/p57/p21 | p27 kip−1/PTEN/KIT | [127,145,169,261,264,265,266,267] |
| miR-224 | PAK4/MMP9 inhibitor-5/SMAD4 | AP15/SMAD4 | [268,269,270,271] |
| miR-27a | PPARγ/FOXO1/APC/P53/RXRα | IL-4/PPARγ | [272,273,274,275] |
| miR-29a/b | PTEN/PI3K/AKT/MMP-2 | IFNARI/ IFN/T-Bet/EOMES/PTEN/MCL-1/ IFN-γ/SLFN4/DNMT3/CDC42/HBP1/TCL1 |
[127,145,182,183,276,277,278] |
| miR-30c | HMBOX1 | PRDMI/P53 | [60,279,280,281] |
| miR-331-3p | ING5 | E2F1/ | [282,283] |
| miR-545/374a | ESRRG | AKT1 | [284,285,286] |
| miR-602 | RASSF1a/STAT3/MYC | NO IDENTIFIED IMMUNE TARGET | [11,287] |
| miR-7 | EGFR/RAF/ERK/PI3K-AKT/MASPIN/MTOR | MTOR/CD98/EGFR/TGB-1 | [206,285,288,289,290,291,292] |