Figure 7.

A mechanistic map depicting the potential role of the HDAC1/LSD1/SESN2 pathway in VC in CRF. HDAC1 regulates the deacetylation of LSD1 promoter region through H3K9ac and then inhibits the expression of LSD1. After the inhibition of LSD1, H3K4me2 binds into the promoter region of SESN2 to promote the expression of SESN2. SESN2 promotes autophagy of VSMCs via mTOR signalling pathway regulation which ultimately alleviated VC in CRF. BUN, blood urea nitrogen; CRF, chronic renal failure; HDAC1, histone deacetylase 1; Runx2, Runt‐related transcription factor 2; SCr, serum creatinine; U‐pro, urine protein; VC, vascular calcification; VPA, valproic acid; VSMCs, vascular smooth muscle cells; α‐SMA, α‐smooth muscle actin