Table 3.
Effects of clinical parameters and hemograms on the arrest of bone marrow and radiodermatitis in NPC patients (n = 507)
| Variables | n | Arrest of bone marrow | Radiodermatitis | ||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | ||
| Sex | 1.428 | 0.845‐2.412 | .183 | 1.234 | 0.767‐1.986 | .385 | |
| Male | 386 | Ref. | Ref. | ||||
| Female | 121 | ||||||
| Age | 1.289 | 0.777‐2.138 | .325 | 0.669 | 0.433‐1.034 | .070 | |
| <60 | 389 | Ref. | Ref. | ||||
| ≥60 | 118 | ||||||
| T | .387 | .735 | |||||
| T1 | 62 | Ref. | Ref. | ||||
| T2 | 149 | 0.828 | 0.400‐1.720 | .613 | 1.220 | 0.629‐2.366 | .556 |
| T3 | 151 | 1.227 | 0.590‐2.549 | .584 | 1.218 | 0.619‐2.395 | .568 |
| T4 | 145 | 0.785 | 0.375‐1.644 | .521 | 0.962 | 0.489‐1.892 | .910 |
| N | .100 | .950 | |||||
| N0 | 40 | Ref. | Ref. | ||||
| N1 | 84 | 0.434 | 0.183‐1.030 | .058 | 0.817 | 0.357‐1.866 | .631 |
| N2 | 305 | 0.494 | 0.231‐1.059 | .070 | 0.915 | 0.436‐1.923 | .815 |
| N3 | 78 | 0.317 | 0.126‐0.797 | .015 | 0.834 | 0.351‐1.984 | .681 |
| M | 1.277 | 0.670‐2.432 | .457 | 1.635 | 0.927‐2.885 | .090 | |
| M0 | 436 | Ref. | Ref. | ||||
| M1 | 71 | ||||||
| Histology | .142 | .495 | |||||
| Keratinizing* | 12 | Ref. | Ref. | ||||
| Non‐Keratinizing# | 479 | 0.361 | 0.099‐1.319 | .123 | 0.414 | 0.097‐1.777 | .235 |
| Unknown | 16 | 0.763 | 0.141‐4.111 | .753 | 0.417 | 0.070‐2.492 | .337 |
| SIRI | 1.219 | 0.615‐2.414 | .571 | 0.852 | 0.452‐1.606 | .621 | |
| <1.529 | 367 | Ref. | Ref. | ||||
| ≥1.529 | 140 | ||||||
| NLR | 0.922 | 0.411‐2.068 | .844 | 1.179 | 0.553‐2.511 | .670 | |
| <3.441 | 377 | Ref. | Ref. | ||||
| ≥3.441 | 130 | ||||||
| SII | 0.935 | 0.432‐2.025 | .865 | 1.069 | 0.505‐2.263 | .861 | |
| <715.739 | 384 | Ref. | Ref. | ||||
| ≥715.739 | 123 | ||||||
| PLR | 1.776 | 0.903‐3.492 | .096 | 1.158 | 0.518‐2.589 | .720 | |
| <245.496 | 442 | Ref. | Ref. | ||||
| ≥245.496 | 65 | ||||||
| WBC | .049 | .850 | |||||
| Normal | 341 | Ref. | Ref. | ||||
| Low | 146 | 0.531 | 0.319‐0.885 | .015 | 1.229 | 0.593‐2.548 | .579 |
| High | 20 | 1.038 | 0.366‐2.945 | .944 | 0.853 | 0.132‐5.489 | .867 |
| RBC | .390 | .335 | |||||
| Normal | 324 | Ref. | Ref. | ||||
| Low | 178 | 1.223 | 0.621‐2.408 | .560 | 1.510 | 0.832‐2.740 | .176 |
| High | 5 | 5.164 | 0.399‐66.905 | .209 | 0.464 | 0.044‐4.942 | .525 |
| HGB | 0.618 | 0.319‐1.198 | .154 | 0.687 | 0.382‐1.236 | .210 | |
| Normal | 330 | Ref. | Ref. | ||||
| Low | 177 | ||||||
| PLT | .476 | .370 | |||||
| Normal | 455 | Ref. | Ref. | ||||
| Low | 15 | 1.008 | 0.225‐4.520 | .992 | 1.501 | 0.420‐5.362 | .532 |
| High | 37 | 1.690 | 0.727‐3.932 | .223 | 1.787 | 0.735‐4.346 | .200 |
| NEU | .591 | .268 | |||||
| Normal | 370 | Ref. | Ref. | ||||
| Low | 109 | 0.834 | 0.380‐1.832 | .652 | 0.557 | 0.270‐1.148 | .112 |
| High | 28 | 0.468 | 0.091‐2.414 | .364 | 0.769 | 0.145‐4.089 | .758 |
| LYM | .001 | .022 | |||||
| Normal | 379 | Ref. | Ref. | ||||
| Low | 127 | 2.939 | 1.655‐5.218 | .000 | 1.878 | 1.202‐2.936 | .006 |
| High | 1 | 7.951E+09 | 0‐ | .999 | 0.000 | 0‐ | .999 |
| MONO | 1.561 | 0.682‐3.577 | 0.292 | 1.063 | 0.502‐2.248 | .873 | |
| Normal | 463 | Ref. | Ref. | ||||
| High | 44 | ||||||
| EO | .000 | .002 | |||||
| Normal | 210 | Ref. | Ref. | ||||
| Low | 290 | 0.343 | 0.227‐0.519 | .000 | 0.502 | 0.342‐0.736 | .000 |
| High | 7 | 0.297 | 0.049‐1.787 | .185 | 1.122 | 0.206‐6.107 | .894 |
| BASO | 0.646 | 0.156‐2.668 | .546 | 0.252 | 0.062‐1.021 | .053 | |
| Normal | 497 | Ref. | Ref. | ||||
| High | 10 | ||||||
| HCT | 0.489 | 0.317‐0.754 | .001 | 0.861 | 0.524‐1.412 | .553 | |
| Normal | 154 | Ref. | Ref. | ||||
| Low | 353 | ||||||
| MCV | .002 | .954 | |||||
| Normal | 483 | Ref. | Ref. | ||||
| Low | 13 | 6.694 | 2.002‐22.377 | .002 | 0.922 | 0.055‐15.414 | .955 |
| High | 11 | 3.154 | 0.831‐11.974 | .091 | 1.277 | 0.262‐6.217 | .762 |
| MCH | .487 | .350 | |||||
| Normal | 485 | Ref. | Ref. | ||||
| Low | 12 | 0.325 | 0.020‐5.256 | .428 | 4.112 | 0.173‐97.498 | .381 |
| High | 10 | 2.246 | 0.390‐12.924 | .365 | 2.934 | 0.466‐18.493 | .252 |
| MCHC | .545 | .619 | |||||
| Normal | 481 | Ref. | Ref. | ||||
| Low | 23 | 1.754 | 0.565‐5.441 | .331 | 1.744 | 0.573‐5.309 | .327 |
| High | 3 | 0.454 | 0.024‐8.660 | .600 | 0.971 | 0.059‐15.998 | .984 |
| RDW | 0.974 | 0.475‐1.997 | .943 | 0.849 | 0.456‐1.581 | .606 | |
| Normal | 436 | Ref. | Ref. | ||||
| High | 71 | ||||||
| MPV | 1.190 | 0.024‐59.676 | .931 | 0.484 | 0.018‐12.830 | .665 | |
| Normal | 505 | Ref. | Ref. | ||||
| High | 2 | ‐ | |||||
Keratinizing squamous cell carcinoma; non‐keratinizing carcinoma.