Table 4.

Effects of clinical parameters and hemograms on the radiation stomatitis and skin pigmentation after radiotherapy in NPC patients (n = 507)

Variables	n	Radiation stomatitis			Skin pigmentation after radiotherapy
		OR	95% CI	P	OR	95% CI	P
Sex		1.211	0.740‐1.984	.446	0.942	0.576‐1.540	.811
Male	386	Ref.			Ref.
Female	121
Age		0.656	0.416‐1.036	.070	1.656	1.027‐2.671	.039
<60	389	Ref.			Ref.
≥60	118
T				.258			.348
T1	62	Ref.			Ref.
T2	149	1.666	0.845‐3.285	.141	0.728	0.362‐1.464	.373
T3	151	1.869	0.931‐3.750	.078	1.176	0.573‐2.415	.658
T4	145	1.306	0.652‐2.613	.451	0.910	0.444‐1.865	.797
N				.645			.454
N0	40	Ref.			Ref.
N1	84	0.804	0.343‐1.885	.616	0.846	0.332‐2.157	.726
N2	305	0.966	0.448‐2.082	.929	0.643	0.277‐1.491	.303
N3	78	0.676	0.275‐1.664	.394	0.936	0.354‐2.476	.894
M		1.503	0.789‐2.862	.215	1.263	0.654‐2.439	.487
M0	436	Ref.			Ref.
M1	71
Histology				.389			.699
Keratinizing*	12	Ref.			Ref.
Non‐Keratinizing#	479	0.913	0.233‐3.585	.897	1.398	0.394‐4.967	.604
Unknown	16	2.192	0.354‐13.578	.399	0.948	0.181‐4.947	.949
SIRI		0.545	0.294‐1.010	.054	1.213	0.618‐2.383	.574
<1.529	367	Ref.			Ref.
≥1.529	140
NLR		1.798	0.904‐3.578	.095	1.200	0.533‐2.705	.659
<3.441	377	Ref.			Ref.
≥3.441	130
SII		0.785	0.356‐1.730	.548	0.862	0.385‐1.929	.718
<715.739	384	Ref.			Ref.
≥715.739	123
PLR		1.341	0.570‐3.158	.501	3.379	1.696‐6.731	.001
<245.496	442	Ref.			Ref.
≥245.496	65
WBC				.229			.082
Normal	341	Ref.			Ref.
Low	146	0.603	0.286‐1.268	.182	0.743	0.349‐1.584	.442
High	20	3.175	0.468‐21.537	.237	8.051	1.209‐53.639	.031
RBC				.201			.282
Normal	324	Ref.			Ref.
Low	178	1.597	0.860‐2.964	0.138	1.667	0.888‐3.126	.112
High	5	0.277	0.027‐2.884	0.283	1.026E+09	0‐	.999
HGB		0.537	0.357‐0.809	0.003	0.646	0.348‐1.198	.165
Normal	330	Ref.			Ref.
Low	177
PLT				.008			.430
Normal	455	Ref.			Ref.
Low	15	1.258	0.411‐3.849	.688	2.534	0.620‐10.355	.195
High	37	4.547	1.743‐11.861	.002	1.074	0.441‐2.618	.875
NEU				.080			.067
Normal	370	Ref.			Ref.
Low	109	0.680	0.417‐1.110	.123	1.594	0.746‐3.405	.229
High	28	0.456	0.175‐1.185	.107	0.179	0.034‐0.945	.043
LYM				.008			.281
Normal	379	Ref.			Ref.
Low	127	2.325	1.365‐3.960	.002	1.756	0.879‐3.508	.111
High	1	1.111E+08	0‐	.999	1.380E+09	0‐	.999
MONO		2.277	1.053‐4.925	.036	1.482	0.657‐3.341	.343
Normal	463	Ref.			Ref.
High	44
EO				.042			.006
Normal	210	Ref.			Ref.
Low	290	0.606	0.406‐0.905	.014	0.525	0.351‐0.784	.002
High	7	1.239	0.222‐6.927	.807	0.408	0.082‐2.027	.273
BASO		0.192	0.044‐0.833	.027	1.558	0.302‐8.027	.596
Normal	497	Ref.			Ref.
High	10
HCT		0.841	0.502‐1.409	.512	0.555	0.359‐0.856	.008
Normal	154	Ref.			Ref.
Low	353
MCV				.987			.222
Normal	483	Ref.			Ref.
Low	13	3.780E+09	0‐	.999	3.925E+09	0‐	.999
High	11	1.143	0.233‐5.609	.869	10.494	0.736‐149.530	.083
MCH				.417			.490
Normal	485	Ref.			Ref.
Low	12	0.000	0‐	.999	0.000	0‐	.999
High	10	3.542	0.544‐23.063	.186	0.300	0.042‐2.160	.232
MCHC				.948			.755
Normal	481	Ref.			Ref.
Low	23	1.157	0.367‐3.650	.803	0.823	0.263‐2.580	.739
High	3	1.447	0.046‐45.566	.834	2.876	0.134‐61.970	.500
RDW		1.001	0.528‐1.895	.998	1.353	0.690‐2.654	.378
Normal	436	Ref.			Ref.
High	71
MPV		0.373	0.014‐9.990	.557	1.712E+08	0‐	.999
Normal	505	Ref.			Ref.
High	2