Table 8.

Univariate and multivariate Cox proportional hazards regression analysis for OS

Variables	Univariate			Multivariate
	HR	95% CI	P‐values	HR	95% CI	P‐values
Therapy			.054
Untreated	Ref.
Chemotherapy	0.277	0.017‐4.515	.367
Radiotherapy	0.086	0.010‐0.718	.023
Sex	1.218	0.478‐3.103	.679
Female	Ref.
Male
Age	3.091	1.359‐7.033	.007	5.061	1.832‐13.983	.002
<60	Ref.			Ref.
≥60
T			.089
T1	Ref.
T2	1.087	0.113‐10.492	.942
T3	1.639	0.191‐14.069	.652
T4	3.920	0.512‐29.990	.188
N			.395
N0	Ref.
N1	1.681	0.174‐16.210	.653
N2	1.108	0.144‐8.548	.922
N3	2.453	0.300‐20.074	.403
M	4.345	1.837‐10.279	.001	3.848	1.204‐12.302	.023
M0	Ref.			Ref.
M1
Histology			.983
Keratinizing*	Ref.
Non‐Keratinizing#	6.277E+04	0‐2.123E+275	.972
Unknown	7.574E+04	0‐2.570E+275	.972
SIRI	4.355	1.789‐10.600	.001	0.785	0.145‐4.250	.779
<1.529	Ref.			Ref.
≥1.529
NLR	4.005	1.633‐9.820	.002	2.354	0.507‐10.935	.275
<3.441	Ref.			Ref.
≥3.441
SII	3.717	1.595‐8.658	.002	0.571	0.085‐3.858	.566
<715.739	Ref.			Ref.
≥715.739
NEU	5.170	1.210‐22.094	.027	5.821	0.881‐38.448	.067
<2.722	Ref.			Ref.
≥2.722
MONO	4.464	1.961‐10.158	.000	1.238	0.338‐4.532	.747
<0.578	Ref.			Ref.
≥0.578
WBC	3.864	1.697‐8.801	.001	3.500	1.422‐8.617	.006
<6.177	Ref.			Ref.
≥6.177
PLT	4.448	1.881‐10.519	.001	1.354	0.385‐4.760	.637
<267.583	Ref.			Ref.
≥267.583
BASO	4.060	1.599‐10.309	.003	1.533	0.511‐4.597	.446
<0.029	Ref.			Ref.
≥0.029
PLR	4.123	1.767‐9.617	.001	3.480	1.090‐11.117	.035
<245.496	Ref.			Ref.
≥245.496
RDW	2.946	1.290‐6.729	.010	3.489	1.380‐8.818	.008
<14.495	Ref.			Ref.
≥14.495