Figure 2.

Histological images of a viral papilloma of Dog 2 under hematoxylin and eosin (H&E) staining and immunohistochemistry (IHC) staining. The benign viral papilloma was taken from a cutaneous mass growing on the abdomen. (a) Hyperpigmented and proliferative epithelia were observed under H&E (40 ×). (b) Several eosinophilic intra-nuclear inclusion bodies (labeled by arrows) were identified in the stratum granulosum (200 ×). (c) Antigen-specific IHC was performed using anti-HPV antibodies (BPV-1/1H8 + CAMVIR; catalog no. ab2417; Abcam, Cambridge, UK). Positive signals (labeled by arrows) were observed on the viral inclusions (400 ×).