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. 2020 Jul 12;12(7):751. doi: 10.3390/v12070751

Table 3.

Gene constellation based on the complete genome sequences of 220 HPAI viruses of H5N1 subtype from Bangladesh available in the databases (Global Initiative on Sharing Avian Influenza Data (GISAID) and National Center for Biotechnology Information (NCBI)).

Genotype Clade 2.2.2 Clade 2.3.4.2 Clade 2.3.2.1c Clade 2.3.2.1a (Old) Clade 2.3.2.1a (Old) with H9N2-like PB1 Clade 2.3.2.1a (New) R1 Clade 2.3.2.1a (New) R2
Gene constellation graphic file with name viruses-12-00751-i001.jpg graphic file with name viruses-12-00751-i002.jpg graphic file with name viruses-12-00751-i003.jpg graphic file with name viruses-12-00751-i004.jpg graphic file with name viruses-12-00751-i005.jpg graphic file with name viruses-12-00751-i006.jpg graphic file with name viruses-12-00751-i007.jpg
Features All eight gene segments are H5N1 HA clade 2.2.2-like. All gene segments are H5N1 HA clade 2.3.4.2-like. All gene segments except M, are H5N1 HA clade 2.3.2.1c-like.
M gene resembling Chinese H9N2 subtype.		 All gene segments are H5N1 HA clade 2.3.2.1a-like. All gene segments except PB1 are H5N1 HA clade 2.3.2.1a-like.
PB1 gene resembling Bangladeshi H9N2 viruses under G1-Western lineage.		 H5N1 HA clade 2.3.2.1a-like HA, NA and M genes.
LPAI-like PB2, PB1, PA, NP, and NS genes.
PA gene resembling H5N1 clade 2.3.2.1a (new) viruses.		 H5N1 HA clade 2.3.2.1a-like HA, NA, and M genes.
LPAI-like PB2, PB1, PA, NP, and NS genes.
PA gene resembling H3N8-like BD LPAI viruses.
Timeline 2007–2011 2011 2012 2011–2015 2011–2015 2013–continuing 2017–continuing
Complete genome sequences available: Year (No.) Total: 12
2007 (1), 2010 (8), 2011 (3)		 Total: 2
2011 (2)		 Total: 2
2012 (2)		 Total: 84
2011 (27), 2012 (32), 2013 (4), 2014 (15), 2015 (6)		 Total: 8
2011 (2), 2012 (2), 2013 (3), 2015 (1)		 Total: 98
2013 (4), 2015 (11), 2016 (25), 2017 (41), 2018 (17)		 Total: 14
2017 (9), 2018 (5)

Note: The gene segment order is based on their length from top to bottom, i.e., Polymerase basic 2 (PB2), Polymerase basic 1 (PB1), Polymerase acidic (PA), Hemagglutinin (HA), Nucleoprotein (NP), Neuraminidase (NA), Matrix (M), and Nonstructural (NS).