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. 2020 Jul 7;25(13):3104. doi: 10.3390/molecules25133104

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Proposed mechanism underlying the anti-inflammatory effects of juglone in macrophages. Pre-treatment of macrophages with juglone suppressed ATP-induced IL-1β, IL-18 and NLRP3 secretion in LPS-primed J774.1 mouse macrophages. Juglone also caused downregulation of ATPase activity and ROS and NO production. Juglone also reduced the mRNA expression and activation of IL-1β, IL-18, NLRP3 and caspase-1. The results show that juglone inhibits IL-1β and IL-18 secretion and NLRP3 formation in activated macrophages.