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Topology of NS4B in the ER membrane. (A) The AH2 amphipathic helix domain can be positioned on the cytosolic face of the ER, along with the amino-terminal AH1 domain. (B) Insertion of AH2 in the ER membrane translocates the AH1 domain to the ER lumen. It is not yet known how altered NS4B topology affects protein function. TM: transmembrane, AH: amphipathic helix.
