Table II.

Comparison of Brain to Plasma AUC of 9 Distinct Small Molecules After IV, SC and IP Administration in the Rat (Tabulated from Data Reported in Durk et al., 2018)

Drug	AUC 0–360, ISF / AUC0–360, plasma
	IV infusion (1 mg/kg/h for 6 h)	Subcutaneous (2 mg/kg every 2 h × 3)	IP (2 mg/kg every 2 h × 3)
Carbamazepine	0.250 ± 0.07	0.779 ± 0.06	1.31 ± 0.23
Citalopram	0.438 ± 0.13	0.450 ± 0.28	0.467 ± 0.15
Desmethylclozapine	0.0902 ± 0.06	NC	0.098 ± 0.04
Diphenhydramine	2.24 ± 0.43	2.43 ± 0.95	3.38 ± 0.94
Gabapentine	0.0153 ± 0.01	0.0622 ± 0.01	0.0747 ± 0.02
Metaclopramide	0.0905 ± 0.02	0.646 ± 0.31	0.747 ± 0.13
Naltrexone	0.441 ± 0.16	1.55 ± 0.67	2.78 ± 0.65
Quinidine	0.154a	NC	0.143 ± 0.05
Risperidone	0.620a	0.776 ± 0.64	0.793 ± 0.20

Values are mean ± S.D. NC, not calculated in the original article.

^a, S.D. was not reported in the orignal article