Table III.
Pharmacokinetic Parameters of Various Small Molecules After IP and Other Routes of Administration in Rodents
| Drug name | MW* | Route | Dose** | Pharmacokinetics |
Ref. | ||
|---|---|---|---|---|---|---|---|
| AUC*** | Cmax # | t max ## | |||||
| Docetaxel | 807.879 | IV | 8 | 4850 | 1.2 | NA | (69) |
| IP | 8 | 3370 | 1.2 | 1 | |||
| Deramciclane | 301.466 | IV | 10 | 3127.53 | 2643 | NA | (71) |
| IP | 10 | 578.18 | 177.8 | 0.166 | |||
| Oral | 10 | 106.95 | 44.94 | 0.5 | |||
| Tariquidar (In DMSO) | 646.73 | IV | 15 | 25,200 | 1.9 | 0.5 | (73) |
| IP | 15 | 23,800 | 1.5 | 2 | |||
| Oral | 15 | 18,100 | 1.2 | 4 | |||
| Tariquidar (Microemulsion) | 646.73 | IV | 15 | 25,200 | 1.9 | 0.5 | (73) |
| IP | 15 | 25,600 | 1.6 | 2 | |||
| Oral | 15 | 21,900 | 1.3 | 3.6 | |||
| Lenalidomide | 259.261 | IV | 10 | 284,000 | 158 | NA | (74) |
| IP | 10 | 300,000 | 8.48 | NA | |||
| Oral | 10 | 214,000 | 2.03 | NA | |||
*
, molecular weight in g/mol
**
, dose in mg/kg
***
, AUC in ng-h/ml
#
, tmax in h
##
, Cmax in μg/ml
NA, not available