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. 2020 Jul 31;11:1629. doi: 10.3389/fimmu.2020.01629

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Copyright © 2020 Lee, Srinivasan, de Anda, Nicastro, Tükel and Wong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional reciprocity of AMPs and amyloids and consequences for host defense and immune signaling. Both AMPs and amyloids are involved in antimicrobial defense, immunomodulation, and homeostasis, but dysregulation can lead to adverse outcomes such as cytotoxicity, chronic inflammation, and autoimmune diseases like lupus, and degenerative diseases like Alzheimer's disease and Parkinson's disease. Further work will be required to elucidate the mechanisms of how such a delicate balance is attained.