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. 2020 Jul 31;14:758. doi: 10.3389/fnins.2020.00758

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Copyright © 2020 Lee, Jiang, McIlmoyle, To, Xu, Hirsch-Reinshagen, Mackenzie, Hsiung, Eadie, Sarunic, Beg, Cui and Matsubara.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Aβ labeling in retina compared to neuritic plaque (NP) scores in cortical regions of AD subjects. (A,B) We compared number of Aβ labeled cells with NP scores. The AD subjects with lower NP scores (Blue: sparse or moderate) in the parietal (A) and temporal (B) cortices show greater number of Aβ labeled cells in the temporal retinal region than those with higher NP scores (Yellow: frequent), using two-samples Wilcoxon test. (C,D) Next, we compared intracellular Aβ load in the retinal ganglion cells with NP scores. The AD subjects with lower NP scores (Blue: sparse or moderate) in the frontal (C) and parietal (D) cortices show greater intracellular Aβ load in the temporal retinal region than those with higher NP scores (frequent), using two-samples Wilcoxon test.