Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 6;17:232. doi: 10.1186/s12974-020-01909-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 4 — Effect of CHIT-1 on glia in different regions of the spinal cord. Representative confocal micrographs showing Iba1 (green) and GFAP (red) expression in the spinal cord sections (a–f). Significant amount of gliosis was noted in the ventral horn (V) compared to dorsal horn (D). The yellow coloured line demarcates the areas (b). The higher magnification images show the presence of astrocytes (red, small arrows, (e)) in the grey matter and also the Iba1 (green, big arrows, (f)) immunoreactive microglia surrounding the motor neurons (*). Scale bars are indicated. Representative confocal photomicrographs showing Iba1 (green) and GFAP (red) expression around the central canal (arrows) (g–o). Note the faint staining in normal control (NC, (g, h, i)) whereas both the markers show upregulation in the 50 and 100 pg concentrations of CHIT-1 (C50 and C100) (j–o). Note the presence of amoeboid shaped microglia within the vicinity of the canal (arrowheads) (o). Scale bars are indicated