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. 2020 Aug 7;21:207. doi: 10.1186/s12931-020-01478-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Gli2 expression is decreased in airway progenitor basal cell nuclei from COPD patients. a. Representative micrograph showing a ROI of a bronchial brushing stained for cilia (Acetylated tubulin, green); Gli2 (Gli2, red); basal cells (p63, white) and cell nuclei (DAPI, blue) in both non-COPD (upper panel) and COPD patients (lower panel). Magnification corresponding to the selected area is shown. Insets depict localization of the Gli2 transcription factor. b. Dot plot with median showing the percentage of Gli2-positive basal cell nuclei in non-COPD (n = 15) and COPD patients (n = 15). ***, p < 0.0001. c. Linear regression of the percentages of Gli2-positive basal cell nuclei according to FEV₁ (% predicted) for non-COPD (n = 15) and COPD patients (n = 15). Non-COPD patients are represented by black circles and COPD patients are represented by red circles