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. 2020 Aug 7;21:207. doi: 10.1186/s12931-020-01478-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Shh activating ligand is deficient in COPD bronchi. a. Representative micrograph showing a ROI of a bronchial brushing stained for basal cells (pancytokeratin, KP, white); Gli2 (green); Ptch1 (red, left panel); Hhip (red, right panel); and cell nuclei (DAPI, blue). Magnification corresponding to the selected area is shown. b. Representative micrograph showing a ROI of a bronchial biopsy stained for cilia (Acetylated tubulin or Arl13b, green); Ptch1 (red, left panel); Hhip (red, right panel); and cell nuclei (DAPI, blue). Magnification corresponding to the selected area is shown. c. Representative micrograph showing a ROI of a bronchial biopsy stained for cilia (Arl13b, green); Shh (red) and cell nuclei (DAPI, blue). Magnification corresponding to the selected area is shown. d. Dot plot with median representing Shh concentrations measured by ELISA in bronchial BALF from non-COPD (n = 15) and COPD patients (n = 15). **, p < 0.001