TABLE 2.
Association of SNPs of candidate genes and odds ratio to PD risk
| Candidate gene | SNP | Effect allele | Allele model a | Dominant model b | Recessive model b | Additive model b | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | |||
| SNCA | rs8180209 | A | .047 | 0.77 (0.60, 0.98) | .138 | 0.74 (0.50, 1.10) | .077 | 0.66 (0.42, 1.05) | .047 | 0.77 (0.59, 0.99) |
| MCCC1 | rs2270968 | G | .091 | 1.27 (0.99, 1.64) | .024 | 1.52 (1.06‐2.19) | .907 | 0.96 (0.50, 1.84) | .084 | 1.28 (0.97, 1.71) |
| DLG2 | rs7479949 | C | .159 | 0.82 (0.64, 1.06) | .322 | 0.82 (0.56, 1.21) | .019 | 0.26 (0.09‐0.80) | .072 | 0.73 (0.52, 1.03) |
| GBF1 | rs10748818 | G | .043 | 0.72 (0.56, 0.92) | .093 | 0.73 (0.50, 1.05) | .089 | 0.60 (0.33, 1.08) | <.001 c | 0.37 (0.25‐0.57) |
| MBNL2 | rs4771268 | T | .011 | 0.72 (0.54, 0.96) | .179 | 0.77 (0.53, 1.12) | .003 c | 0.48 (0.29‐0.78) | .015 | 0.73 (0.56‐0.94) |
Abbreviations: CI, confidence interval; OR, odds ratio; PD, Parkinson's disease; SNP, single nucleotide polymorphism.
a
P value, OR and 95% CI were obtained from risk analysis and refer to the risk allele.
b
Adjusted for age and gender.
c
The statistical significances remained after using Bonferroni correction.
Bold values are indicate the significant results