TABLE 3.
Association of SNPs of candidate genes and odds ratio to LOPD risk
| Candidate gene | SNP | Effect allele | Allele model a | Dominant model b | Recessive model b | Additive model b | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | |||
| SNCA | rs8180209 | A | .052 | 0.77 (0.59‐1.00) | .146 | 0.74 (0.49, 1.11) | .064 | 0.94 (0.65, 1.37) | .044 | 0.76 (0.57, 0.99) |
| MCCC1 | rs2270968 | G | .152 | 1.23 (0.93‐1.64) | .042 | 1.48 (1.01, 2.16) | .822 | 0.92 (0.46, 1.85) | .130 | 1.26 (0.93, 1.10) |
| DLG2 | rs7479949 | C | .074 | 0.77 (0.59‐1.03) | .135 | 0.74 (0.49, 1.10) | .015 | 0.21 (0.06, 0.74) | .022 | 0.66 (0.46, 0.94) |
| GBF1 | rs10748818 | G | .059 | 0.77 (0.58‐1.01) | .129 | 0.74 (0.50, 1.09) | .075 | 0.56 (0.30, 1.06) | <.001 c | 0.41 (0.27, 0.62) |
| MBNL2 | rs4771268 | T | .015 | 0.71 (0.54‐0.94) | .130 | 0.74 (0.50, 1.09) | .007 | 0.48 (0.29, 0.82) | .015 | 0.72 (0.55, 0.94) |
| TRIM40 | rs9261484 | T | .130 | 1.26 (0.93‐1.70) | .039 | 1.49 (1.02, 2.18) | .926 | 0.96 (0.43, 2.16) | .118 | 1.28 (0.94, 1.75) |
Abbreviations: CI, confidence interval;LOPD, late‐onset Parkinson's disease; OR, odds ratio; SNP, single nucleotide polymorphism.
a
Adjusted for age and gender.
b
P value, OR and 95% CI were obtained from risk analysis and refer to the risk allele.
c
The statistical significance remained after using Bonferroni correction.
Bold values are indicate the significant results